Structure-energy-based predictions and network modeling of RASopathy and cancer missense mutations
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چکیده
Thank you again for submitting your work to Molecular Systems Biology. We have now heard back from the three referees who agreed to evaluate your manuscript. As you will see from the reports below, the referees acknowledge that the presented analysis of RASopathy mutations in relation to cancer mutations yields potentially interesting findings. However, they raise a series of concerns, which should be carefully addressed in a revision of the manuscript.
منابع مشابه
Structure‐energy‐based predictions and network modelling of RASopathy and cancer missense mutations
The Ras/MAPK syndromes ('RASopathies') are a class of developmental disorders caused by germline mutations in 15 genes encoding proteins of the Ras/mitogen-activated protein kinase (MAPK) pathway frequently involved in cancer. Little is known about the molecular mechanisms underlying the differences in mutations of the same protein causing either cancer or RASopathies. Here, we shed light on 95...
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